Alopurin contains the active substance allopurinol, which is a medicine that inhibits the formation of uric acid (uricostatic).
Alopurin is indicated:
Adults
• in cases where blood uric acid values are 500 μmol (8.5 mg/100 ml) and above, provided it is dietary unmanageable, or in clinical complications with hyperuricemic conditions, especially manifested gout, renal damage caused by uric acid (urate nephropathy), treatment and prevention of uric acid stones, and to prevent the formation of calcium oxalate stones in concomitant hyperuricemia;
• in raised blood uric acid levels and increased excretion of uric acid in urine, e.g. in strong cell decay, radiation or chemotherapy (secondary hyperuricemia).
Children
• in raised blood uric acid levels and increased excretion of uric acid in urine, e.g. in strong cell decay, radiation or chemotherapy (secondary hyperuricemia);
• in renal damage caused by uric acid (urates nephropathy) during treatment of leukemia;
• in congenital enzyme deficiency disease (Lesch-Nyhan syndrome [partial or total defects of the hypoxanthine-guanine phosphoribosyl transferase] and adenine phosphoribosyltransferase deficiency).