Chloramphenicol is a bacteriostatic antibiotic with a broad spectrum of action.
Chloramfenicol is rapidly absorbed by the intestinal tract, while its bioavailability is 75% up to 90 %. The maximal plasmatic concentration is 10 up to 200 mcg/ml. About 60% of the chloramphenicol is bound with plasmatic proteins. Chloramphenicol enters in the cerebrospinal fluid, even in the absence of inflammed meninges. The general urinary excretion of chloramphenicol fluctuates from 68% up to 99% for three days. The major part of chloramphenicol present in blood is in the active form. The elimination half-life of chloramphenicol is about 4 hours.
Kloramfenikol tablets are used in life-threatening infections, mainly those caused by Haemophilus influenzae, and in the typhoid fever.