Klorpromazine

Klorpromazine – 50 mg / 2 ml Solution for injection

Chlorpromazine is the first antipsychotic in practice that represents the aliphatic phenothiazines. It has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and some weak antimuscarinic activities.
Chlorpromazine is a dopamine inhibitor and stimulates the release of prolactin. There is some evidence that the antagonism of central dopaminergic function, especially at the D2-dopaminergic receptor, is related to the therapeutic effect in psychotic conditions. Chlorpromazine possesses sedative properties but patients usually develop tolerance rapidly to sedation. It has antiemetic, serotonin-blocking, and weak antihistaminic properties and slight ganglion-blocking activity. Chlorpromazine inhibits the heat-regulating center so that the patient tends to acquire the temperature of the surroundings. Chlorpromazine can relax skeletal muscles.

Chlorpromazine sugar-coated tablet and solution for injection is used:
• in acute and chronic schizophrenia in adults and children;
• to reduce acute mania, as in bipolar disorder;
• in the control of agitated, or violent behavior in adults and children and sometimes other psychiatric conditions;
• in autistic children;
• as an adjunct for the short-term treatment of severe anxiety, and to reduce pre-operative anxiety in adults and children;
• as an antiemetic in some forms of nausea and vomiting in adults and children; it is ineffective in motion sickness;
• in the alleviation of intractable hiccup;
• as an adjunct in the treatment of tetanus in adults and children and to control symptoms in acute intermittent porphyria;
• for induction of hypothermia;
• in surgery – preparation for anesthesia, prophylaxis and treatment of states of shock;
• in obstetrics – obstetric analgesia, eclampsia.