Koronarine

Koronarine – 25 mg Sugar-coated tablets

Koronarine contains dipyridamole as active substance. Dipyridamole prolongs the abnormally decreased survival time of platelets. It is an inhibitor of the platelets aggregation, although the mechanism of action has not been fully clarified.
The mechanism of action is related to:
1) adenosine reuptake inhibition from erythrocytes, which in turn is an inhibitor of the platelet reactivity;
2) inhibition of phosphodiesterase, which leads to the increased cyclic adenosine – 3′, 5′ monophosphate in platelets and
3) inhibition of thromboxane A2, which is a powerful stimulant of platelet activation.

Koronarine 25 mg sugar-coated tablets are used as adjunct during treatment with anticoagulants taken by mouth (coumarin anticoagulants) for the prophylaxis of thromboembolic complications from prosthetic heart valves. Alone or in combination with aspirin it is indicated also for the prevention of myocardial infarction and to reduce mortality from myocardial infarction.