Levomepromazine

Levomepromazine – 25 mg Sugar-coated tablets

Levomepromazine belongs to the group of phenothiazine neuroleptics.
It acts on hypothalamus, thalamus, reticular formation and on lymbic system, inhibiting the sensory impulses.
Levomepromazine antagonizes dopamine D2 receptors, 5HT3-serotonin receptors, histamine H1 receptors, and cholinergic (muscarinic) receptors.
As a result of this antagonism appears a calming effect in small doses, an antipsychotic effect in high doses, as well as increase of the threshold of pain and stimulation of amnesia.
Levomepromazine also has analgesic, antihistaminic and anticholinergic effect.
This medicine does not cause respiratory depression, therefore it is useful especially in patients with low respiratory reserve.

Levomepromazine is used in the treatment of:
• psychoses, to control agitation and psychomotor agitation in moderately severe depression;
• schizophrenia;
• psychotic disorders with hallucinations;
• personality disorders in patients with epilepsy;
• neurotic disorders;
• as an analgesic to relieve moderate to severe pain prior to surgery;
• incoercible vomiting.