Nifedipine

Nifedipine – 10 mg Sugar-coated tablets

Nifedipine is a dihydropyridine calcium-channel blocker.
It inhibits the calcium ions flow through the cellular membrane. Nifedipine decreases the myocardial oxygen demand. It is a peripheral and coronary vasodilator, but, unlike the other calcium-channel blockers verapamil or diltiazem, has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses.
Nifedipine has no antiarrhythmic activity.
It widens the main coronary arteries and coronary arterioles, both in normal region but also in ischemic ones and is a strong inhibitor to their spasms. It lowers blood pressure at rest and at a certain level of stress. This is realized by widening peripheral arterioles and reducing total peripheral resistance.

Nifedipine 10 mg sugar-coated tablet is used in:
• angina;
• Raynaud’s disease;
• hypertension.
Nifedipine sugar-coated tablets can increase the risk of serious heart problems in patients with hypertension or angina. Hence, Nifedipine sugar-coated tablets are only used in these patients if no other treatments are appropriate.