Amitriptiline is a tricyclic antidepressant that has a structure with three rings. It inhibits the neuronal reuptake of noradrenaline and of serotonine (5HT) in the central nervous system. The inhibition of these monoamino-neurotransmitters, which potentiate the action of amitriptyline in the brain, seems to be related with its antidepressant activity. If the sedative effect and other side effects of amitriptyline are observed at the beginning of the treatment, the antidepressant effect is noticed only after some weeks.
Amitriptiline sugar-coated tablets are used:
• in all the depressive conditions such as: melancholy, manic – depressive psychosis, neurotic depressions, depressions during the nonmelancholic psychosis, anxiety, discontent for life, avoidance of family life and society, decreased professional performance, neurovegetative disbalance, psychosomatic disorders and hypochondriasis;
• in enuresis (when the organic pathology is excluded).