Analgine contains the active substance metamizole sodium, which has a significant analgesic and antipyretic effect, but its anti-inflammatory effect is weak. It has also a spasmolytic effect on the smooth muscles of the uterus, gallbladder and urinary tract. It inhibits the synthesis of prostaglandins through inhibition of cyclooxygenasis. The central analgesic action is due to the inhibition of the activation of adenylatecyclase.
It is indicated in severe or resistant conditions with pain or temperature.
Metamizole sodium is rapidly and completely absorbed after oral administration. The maximal plasmatic concentration is obtained after one hour. It is partially bound to plasmatic proteins. The drug is metabolised in the liver.