Librian

Librian – 10 mg Sugar-coated tablets

Librian contains the active substance chlordiazepoxide, which like all other benzodiazepines, potentiates the effects of the gamma-aminobutiric acid (GABA) (facilitates the inhibitory neurotransmition of GABA) and of the other inhibitory neurotransmitters, by binding with the specific benzodiazepinic receptors. The potentiation of the effects of GABA causes the inhibition of the central nervous system.
Librian is almost completely absorbed after oral administration. It is highly bound (about 96%) to plasmatic proteins, while its elimination half-life is from 5 to 30 hours. Chlordiazepoxide passes in the cerebrospinal fluid and in breast milk, as also in the placenta. Metabolites
pharmacologically active of chlordiazepoxide are: desmethylchlordiazepoxide, demoxepam, desmethyldiazepam and oxazepam. The unchanged drug and the metabolites are excreted through urine, mainly as coniugated metabolites.

Librian sugar-coated tablets are used in the:
• short-term treatment of severe conditions of anxiety and tension, which occur alone or accompanied with insomnia or organic disorders;
• treatment of muscular spasms with a psychogen and neurogen origin;
• relief of symptoms from acute alcohol withdrawal;
• relief of concerns and anxiety before surgical interventions.