Pethidine is a synthetic opioid analgesic that acts mainly as an opioid agonist of μ-receptors. Pethidine has the same action and use with morphine, but it is more lipid-soluble than morphine and has a less potent and shorter-lasting analgesic effect. Its analgesic effect lasts for 2 to 4 hours.
Petidine is indicated in:
• the relief of pain in malignant tumors;
• severe neuritis;
• birth activity disorders (severe contractions associated with pain during dilatation over 3 cm);
• acute pulmonary edema;
• calming of spasms of smooth muscles of the digestive tract, biliary and urinary routes;
• premedication before general anesthesia;
• the relief of postoperative pain.