Vitamina B12

Vitamina B12 – 500 mcg / ml Solution for injection

Vitamin B12 (cyanocobalamin) takes part in all the metabolic processes of the organism and plays an important role especially in the synthesis of nucleoproteins. It is necessary for the development, normal haemopoiesis, the formation of the epithelial cells and for the maintenance of the normal function of the neuronal myelinic membranes. Cyanocobalamin is converted in two coenzimes: methylcobalamine (the convertion of homocysteine in methyonine) and deoxyadenosilcobalamine (the convertion of methylmalonylcoenzime A in succinylcoenzime A). These active coenzimes are essential for the development and replication of the cells of the organism. Cobalamin forms a prosthetic group of the methyonine-synthesis and acts as a carrier of the methyl group. The failure of this biochemical reaction because of the deficiency of cobalamine causes the development of megaloblastic anemia and neuropathy.
Vitamin B12 is rapidly absorbed from the injection site. The maximal levels in the serum are achieved within 1 hour after use. Vitamin B12 is bound to serum proteins. It is accumulated in the liver, from where it is slowly released. Within 48 hours after the injection of 100 to 1000 mcg, about 50 % to 98 % of these doses appear in the urine. Most of them are excreted within the first 8 hours.

Vitamina B12 solution for injection is indicated in the treatment and prophylaxis of the hematological and neurological disorders because of the deficiency of vitamin B12 such as: reduction of the absorption of vitamin B12, eg. in pernicious anemia, total or subtotal gastrectomia, Crohn disease and idiopathic steatorrhea, disorders of the intestinal flora accompanied with tropical psylosis (diarrhea), multiple diverticula of the small intestine, infestation with the parasite Diphyllobotrium latum, methylmalonic aciduria and in strict vegetarians and children fed from vegetarian mothers.